Frequency of CYP2C19 Gene Polymorphism and Its Impact on Clinical Outcome among Ischemic Heart Disease Patients Taking Clopidogrel after Percutaneous Coronary Intervention

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dc.contributor.author Abdelsattar, Ahmed
dc.date.accessioned 2020-12-20T08:44:13Z
dc.date.available 2020-12-20T08:44:13Z
dc.date.issued 2020
dc.identifier.citation Abdelsattar, A.(2020).Frequency of CYP2C19 Gene Polymorphism and Its Impact on Clinical Outcome among Ischemic Heart Disease Patients Taking Clopidogrel after Percutaneous Coronary Intervention.[Unpublished master's thesis].Misr University for science and technology. en_US
dc.identifier.uri http://dspace.must.edu.eg/handle/123456789/786
dc.description.abstract Introduction : Clopidogrel is an oral thienopyridine derivative is capable of inhibiting platelet activation. Clopidogrel is a prodrug that is converted into an active drug by hepatic cytochrome CYP2C19, CYP2C19*2 and CYP2C19*3 polymorphic alleles are considered to be important loss-of-function alleles resulting in diminished response to clopidogrel. Aim of the work :our study aimed to detect frequency of CYP2C19 gene polymorphisms and its impact on clinical outcome in ischemic heart disease patients treated by clopidogrel. Patients and methods: blood samples were collected from 102 ischemic heart disease patients and the gene frequency was determined by PCR and all patients were followed by clinical assessment and invasive and non-invasive cardiac investigations. Results: frequency of CYP2C19*1 was 50%, CYP2C19*2 was 15% and CYP2C19*3 was 1%, CYP2C19*17 was 34%, patients with recurrent ischemic attacks 37patients (35.8%),from those patients, 10 patients were normal metabolizer (27%),and 27 patients were abnormal metabolizers(73%) with p-value 0.047 to myocardial infarction and 0.020 to unstable angina. Conclusion: A significance relation was found between CYP2C19 polymorphism and recurrent ischemic attacks in this study and multicenter studies are required to confirm this results. en_US
dc.subject clopidogrel en_US
dc.subject thienopyridine en_US
dc.subject cytochrome en_US
dc.subject metabolizer en_US
dc.title Frequency of CYP2C19 Gene Polymorphism and Its Impact on Clinical Outcome among Ischemic Heart Disease Patients Taking Clopidogrel after Percutaneous Coronary Intervention en_US
dc.type Thesis en_US


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