Effect of narrow-band ultraviolet B on the level of interleukin-17 in psoriasis patients


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dc.contributor.author El Shiemy, Saleh M.
dc.contributor.author Abd Allah, Marwa A.
dc.contributor.author Abd Allah, Tarek N.
dc.contributor.author El Fangary, Mona M.
dc.contributor.author Saudi, Wael M.
dc.contributor.author Sayed, Ahmed M.
dc.date.accessioned 2018-04-03T13:22:19Z
dc.date.available 2018-04-03T13:22:19Z
dc.date.issued 2013-03-12
dc.identifier.issn 1687-1537
dc.identifier.uri http://dspace.must.edu.eg/handle/123456789/708
dc.description https://journals.lww.com/jewds/Fulltext/2013/05000/Effect_of_narrow_band_ultraviolet_B_on_the_level.7.aspx en_US
dc.description.abstract Background Psoriasis is a chronic inflammatory skin disease that is thought to be mediated by T helper (Th1) cells. Interestingly, recent advances by cellular immunologists have led to the identification of a new distinct type of T cell called Th17 cells that may play an essential pathogenic role in psoriasis. Objective The present study was planned to study the effect of narrow-band ultraviolet B (NB-UVB) on serum levels of interleukin-17 (IL-17) in psoriasis patients. Patients and methods In this study, we estimated serum levels of IL-17 in 20 psoriatic patients before and after 36 sessions of NB-UVB and in 10 healthy controls using enzyme-linked immunosorbent assay, correlating their levels with disease severity, which was calculated using the psoriasis area severity index. Results The mean serum levels of IL-17 were significantly elevated in patients with psoriasis in comparison with those in normal controls. Moreover, there was significant elevation in mean serum IL-17 levels of psoriatic patients before treatment compared with those after treatment. Conclusion Psoriasis is a Th1 and Th17-mediated inflammatory skin disease, and NB-UVB has a significant inhibitory effect on both serum levels of IL-17 and psoriasis area severity index scores. en_US
dc.language.iso en en_US
dc.publisher Egyptian Women’s Dermatologic Society en_US
dc.relation.ispartofseries Journal of the Egyptian Women’s Dermatologic Society;
dc.subject narrow-band ultraviolet B en_US
dc.subject psoriasis en_US
dc.subject serum interleukin-17 en_US
dc.title Effect of narrow-band ultraviolet B on the level of interleukin-17 in psoriasis patients en_US
dc.type Article en_US

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