Abstract:
The aim of this study was to evaluate the effect of vitamin E, silymarin and their co-administration on
oxidative stress and hormonal changes in rats whole body exposed to 950 MHz electromagnetic field (EMF) for
2months (2hrs/day, 3times/week). Vitamin E (1.35mg/Kg BW) and/or silymarin (18mg/Kg BW) were orally
administered to rats for 2months before EMF exposure. Exposure to EMF provokes oxidative stress identified by
significant increases in serum thiobarbituric acid reactive substances (TBARS), advanced oxidation protein products
(AOPP) and protein carbonyl (CO) levels associated to significant decreases in superoxide dismutase (SOD),
catalase (CAT), and glutathione peroxidase (GSH-Px) activities and glutathione (GSH) content. Oxidative stress was
accompanied by significant decreases of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), and
total and free testosterone levels. Vitamin E as well as silymarin has significantly reduced oxidative stress and
ameliorated hormone levels. It is concluded that the co-administration of vitamin E with silymarin would provide a
better protection against EMF-induced biological hazards.
