Stability Indicating Spectrophotometric Methods For Determination Of Nicardipine In The Presence Of Its Alkaline Induced Degradation Products

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dc.contributor.author Lotfy, Hayam Mahmoud
dc.contributor.author Hegazy, Maha Abd El-Monem
dc.contributor.author Abd El-Aziz, Mai M
dc.contributor.author Abdel Fattah, Laila Elsayed
dc.date.accessioned 2017-08-30T10:55:13Z
dc.date.available 2017-08-30T10:55:13Z
dc.date.issued 2016
dc.identifier.citation en_US
dc.identifier.citation Lotfy, Hegazy, M., Abd El-Aziz, M., & Abdel Fattah, L. (2016). Stability Indicating Spectrophotometric Methods For Determination Of Nicardipine In The Presence Of Its Alkaline Induced Degradation Products. International Journal of Pharmacy and Pharmaceutical Sciences, 8(3).
dc.identifier.issn 0975-1491
dc.identifier.uri http://dspace.must.edu.eg/handle/123456789/197
dc.description.abstract Objective: Derivative, ratio spectra derivative and ratio difference spectrophotometric methods were developed and validated for simultaneous determination of Nicardipine (NIC) in the presence of its alkaline induced degradation products. Methods: In these methods the overlapped spectra of NIC and its alkaline induced degradation products were well resolved by measuring the amplitudes of first derivative (DP1P) spectra and the second derivative (DP2P) at 382.3 and 239 nm, respectively. NIC was determined by ratio spectra derivative by measuring the amplitude at 244 nm. The ratio difference spectrophotometric method was developed in which the difference between amplitudes at 237.5 nm and 260 nm of the ratio spectra were recorded. The linearity range for the applied methods was 2-18 μg/ml. Results: All the developed methods were validated according to ICH Guidelines, NIC was determined with acceptable accuracy and precision. Conclusion: These methods were suitable as stability indicating methods for the determination of NIC in the presence of its alkaline induced degradation products either in bulk powder or in a pharmaceutical formulation. Statistical analysis of the results with those obtained by applying a reported method has been carried out revealing high accuracy and good precision. en_US
dc.language.iso en en_US
dc.publisher International Journal Of Pharmacy And Pharmaceutical Sciences en_US
dc.relation.ispartofseries International Journal of Pharmacy and Pharmaceutical Sciences;Vol 8, Issue 3
dc.subject Nicardipine, Spectrophotometry, Pharmaceutical preparations, Stability indicating, derivative, ratio derivative and ratio difference en_US
dc.subject Spectrophotometr
dc.subject Pharmaceutical preparations
dc.subject Stability indicating
dc.subject derivative
dc.subject ratio derivative and ratio difference
dc.title Stability Indicating Spectrophotometric Methods For Determination Of Nicardipine In The Presence Of Its Alkaline Induced Degradation Products en_US
dc.type Article en_US


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